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  • Hexidine 80ml

    Composition:

    Chlorhexidine gluconate solution I.P. diluted to chlorhexidine gluconate 0.2% w/v in a pleasantly flavoured base.

    Understanding Chlorhexidine gluconate:

    1. Chlorhexidine (CHX) is known as the gold standard antiplaque agent because of its persistent attachment and sustained release for long Antiseptic, Antiplaque, Antiviral, Antifungal action.
    2. Five decades of evidence for the antibacterial, antiviral, antifungal action.
    3. Chlorhexidine’s antiplaque effect is because of its dicationic nature, which confers it the property of substantivity— persistent antimicrobial action through bactericidal and bacteriostatic effects.

    Mechanism of action:

    1. Chlorhexidine is a symmetric bis-biguanide molecule carrying two positive charges at physiological pH. Due to its cationic properties, chlorhexidine binds to  negatively charged sites within the plaque biofilm including the bacteria, extracellular polysaccharides, and glycoproteins.
    2. The cationic chlorhexidine molecule gets rapidly attracted to the surface of a negatively charged bacterial cell wall, where it binds with specific and strong adsorption to phosphate-containing components of the bacterial cell wall.
    3. Due to the strong binding, chlorhexidine passively diffuses through the bacterial cell wall.
    4. First, chlorhexidine damages the outer cell membrane compromising the cell integrity, which allows chlorhexidine to infiltrate the inner cell membrane, resulting in greater permeability.
    5. This infiltration results in an outflow of low-molecular-weight molecules and cytoplasmic components escaping from the bacterial cell.
    6. At this point, chlorhexidine’s antimicrobial action remains bacteriostatic, which can be reversed if chlorhexidine is removed. However, if the chlorhexidine concentration remains stable over time or increases, it can cause irreversible cell damage via bactericidal action.
    7. The bactericidal action involves cytoplasmic coagulation and precipitation, where chlorhexidine forms complexes with phosphorylated compounds, such as ATP and nucleic acids.
    8. The dicationic chlorhexidine exhibits good adherence to most oral surfaces (including mucous membranes, teeth, and salivary glycoproteins) due to their negative charge, thus interfering with bacterial adhesion, allowing substantivity for up to 12 hours.

    Chlorhexidine the Gold standard antiplaque agent

    1. Chlorhexidine is the gold standard when it comes to substantivity, which explains its superior
    anti-plaque effect because of its superior degree of persistence at the tooth surface (hydroxyapatite) or, more correctly, the superior persistence of its antibacterial effect (both bactericidal and bacteriostatic) at the tooth surface.
    2. Chlorhexidine comes under Group A mouthwashes with good substantivity (prolonged action) as well as action on a wide spectrum of bacteria. The only category of mouth rinses belonging to this group are bisguanides (Chlorhexidine). The true anti-plaque effect of Chlorhexidine empowers it to replace mechanical cleaning for short periods when tooth brushing is not possible.

    Indications:

    1. Prevention & treatment of gingivitis. For home use between periodontal treatment visits.
    2. Minimizing plaque build up in the absence of brushing.
    3. Fungal infections of the mouth: oral candidiasis, denture stomatitis.
    4. Secondary bacterial infections for aphthous ulcer.
    5. Rinsing & gargling for oropharyngeal viral infections.
    6. Alveolar osteitis (dry socket) prevention.
    7. Reducing viral spread from oropharyngeal region by reducing the viral load
    8. As a pre-procedural rinse before dental procedures.
    9. Patients undergoing cancer therapy who can not perform mechanical plaque control due to pain and discomfort in the gingiva and oral mucosa.
    10. Post-surgical mouthwash: If toothbrushing is not possible due to postoperative pain after any type of oral, periodontal, soft tissue surgery, or extractions, it is recommended that a 1-minute rinse is performed 3 times a day for 7 days or until sutures are removed and oral hygiene in the form of toothbrushing can resume.

    Directions for use:

    1. Recommended only under professional guidance.
    2. Recommended twice daily oral rinsing for 30 seconds at least, morning and evening after toothbrushing. Fill the cap up to 10 ml mark and swish in mouth undiluted for 30 seconds at least, and spit out.
    3. For best results, rinse at least 30 minutes after toothbrushing, and avoid eating / drinking for at least 30 minutes after rinsing.
    4. For denture stomatitis, cleanse and soak dentures in chlorhexidine mouthwash solution for 15 minutes twice daily.
    5. Prolonged use may cause temporary staining of teeth, removed by oral prophylaxis. This usually disappears once the treatment is over, or may require scaling/ polishing. However, staining is known to occur only after continuously using for 4 weeks or more.

    Presentation:

    PET bottles of 80ml (2.7 fl.oz.), 160ml (5.41 fl.oz.) with 10ml measuring cap. Plastic bottle of 500 ml (16.9 fl. oz.).

    Caution:

    Not to be swallowed. For oral use only.

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  • Hexidine EP 150ml

    Chlorhexidine Mouthwash IP/BP

    Composition:
    Chlorhexidine gluconate solution I.P. dilute to chlorhexidine gluconate 0.12% W/V in pleasantly flavored aqueous base.

    COLOR:
    Brilliant Blue & Tartrazine Yellow

    Indications:

    1. Prevention of plaque in absence of brushing
    2. Prevention and treatment of gingivitis
    3. Treatment of oral candidiasis
    4. Controlling secondary bacterial infections for aphthous ulcers
    5. Aid in treatment of mouth and throat infections

    DIRECTION FOR USE:
    For treatment and prevention, swish in your mouth for one minute. Do not rinse, eat or drink thereafter for 20 minutes. Recommended only under professional guidance.

    DOSE:
    10ml, twice a day.

    STORAGE:
    Keep out of direct sun light.

    WARNING:

    NOT TO BE SWALLOWED. FOR ORAL USE ONLY. Brown staining of teeth may be reported, while using the product in some cases. This usually disappears once the treatment is over or may require scaling/polishing. Remove foil before use.

    Net content: 150 ml/500 ml

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  • Hexigel 15gm

    Composition:

    Chlorhexidine gluconate solution I.P. equivalent to chlorhexidine gluconate 1.0% w/w in pleasantly flavoured base.

    The use of Chlorhexidine gel:

    The application of chlorhexidine (CHX) gel on ulcers and wound surfaces after oral surgical procedures has received considerable attention— supported scientifically by the antimicrobial properties of chlorhexidine.
    Chlorhexidine acts against bacteria (Gram-positive and Gram-negative), with bacteriostatic action at low concentrations and bactericidal action at high concentrations Chlorhexidine is also known for its antiviral and antifungal effects.

    Mode of action:

    Chlorhexidine acts on the target micro-organisms by increasing their cell membrane permeability which causes the precipitation of cytoplasmic macromolecules and subsequent microbial death via cell lysis. Therefore, the effect of CHX is mainly based on minimizing the microbial load —playing an anti-infection role, which seems critical in the early stages of wound healing.

    Indications:

    1. Periodontal diseases: gingivitis, periodontitis
    2. Oral candidiasis, esp denture stomatitis
    3. Aphthous and other oral ulcers, such as due to dentures
    4. Common oral injuries, including those from orthodontic appliances and oral surgery appliances
    5. Maintenance of oral hygiene, especially interdentally — in cancer patients, gingivitis & periodontitis patients, between and around restorations

    Scientific basis in various clinical applications:

    A. Hexigel in the prevention of alveolar osteitis (dry socket)

    The extraction of third molars is a common dental procedure. The American Association of Oral and Maxillofacial Surgeons states that “about 85% of third molars will eventually need to be removed”.
    Available data also shows that 5 to 30% third molar extractions can create a”dry socket” – a complication associated with severe pain.
    How can we prevent this unwanted complication?
    1. A meta-analysis published in “Oral Diseases” in August 2016, reviewed 11 trials and found that 0.2% chlorhexidine gel was effective in preventing alveolar osteitis after lower third molar extraction(s).
    https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.12553
    2. Journal of Oral & Maxillofacial Surgery in May 2017, reviewed Twenty-three studies published from 1979 to 2015 and concluded that chlorhexidine, used in any formulation and concentration can prevent dry socket in patients who have undergone third molar extraction. https://www.joms.org/article/S0278-2391(17)30020-4/fulltext
    3. Another systematic review & meta-analysis published in May 2017 found that Chlorhexidine gel is superior to placebo in reducing the incidence of alveolar osteitis after mandibular third molar extraction.
    https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-017-0376-3
    4. The largest network meta-analysis done till now reviewed 37 randomized controlled trials that included 6175 mandibular third molar surgeries in 4716 patients. This study published in Sept 2020 showed that 0.2% Chlorhexidine gel placed in the socket can prevent dry socket after mandibular third molar surgery.
    https://www.sciencedirect.com/science/article/abs/pii/S1010518220301578
    Hexigel, a 1% Chlorhexidine gluconate-based gel, is an inexpensive and easily available local application for all the 3rd molar extraction patients. They can apply it multiple times a day from the day of tooth extraction. A single tube of Hexigel contains enough quantity of gel to give protective coverage during the critical phase of the first couple of days.

    Use Hexigel after every case of lower molar extraction, especially the surgical extraction of the lower wisdom tooth, and minimize the risk of dry socket.

    B. Hexigel as a post-surgical gel

    High-quality articles demonstrate the evidence that Chlorhexidine gel application
    exerts a beneficial effect on oral surgical wound healing. Chlorhexidine gel
    application significantly decreases the risk of surgical complications and/or poor
    wound healing.

    C. Hexigel in denture stomatitis

    Denture stomatitis (DS) seen in about 15-70% of denture wearers is a condition characterized by a generalized inflammation of the denture-covered palatal mucosa. The clinical signs can vary from petechiae to generalized inflammation with papillary hyperplasia.

    It is a harmless form of oral candidiasis associated with a quantitative increase of yeasts (a mixture of Candida species eg. C. albicans, C. tropicalis, C. krusei, C. guilliermondii, C. glabrata) on the mucosa and the denture’s fit surface. Complete and removable dentures accumulate, among all, C. albicans on the porous surface of the acrylic resin.

    Denture hygiene is an important factor in the prevention and treatment of DS. Chlorhexidine digluconate, an effective antimicrobial agent active against various bacteria, viruses, and fungi including C. albicans, is recommended in the treatment of denture stomatitis because of its proven clinical and microbiological efficacy.

    D. Hexigel in cancer patients

    Patients can use an interdental brush dipped in chlorhexidine gel to clean the areas between teeth, crowns, and bridges to ensure good oral health.

    E. Hexigel in periodontitis patients

    Cleaning the interdental areas is a critical component of oral care in periodontitis patients.

    F. Hexigel in restorative dentistry

    Restorations with overhangs and rough edges can create plaque-retentive areas around the crowns, bridges, and fillings. Cleaning the interdental areas is critical to maintaining soft tissue health interdentally. Cleaning the interdental areas is a critical component of oral care in periodontitis patients.

    Directions for use:

    For oral hygiene, plaque inhibition and gingivitis: Brush your teeth with the gel once or twice a day. Use an interdental brush for carrying hexigel between teeth, crowns, bridges, and implants. For management of aphthous and other oral ulcers: Apply the gel to affected areas once or twice a day.

    Warning:

    Brown staining may be reported with extensive use in some cases. It can be removed by brushing or polishing.

    Presentation:

    Lamitube of 15g (0.52 oz)

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  • Heximetro 15gm

    Composition:

    Chlorhexidine Gluconate 1% w/w, Metronidazole 1% w/w, Lignocaine 2% w/w

    Introduction:

    Heximetro is an antiseptic mouth gel with triple action- that synergistically acts against both —aerobic and anaerobic pathogens in oral lesions, and also provides instant pain relief via topical anaesthesia.

    Chlorhexidine:

    Chlorhexidine is a well-known antiseptic, and antimicrobial agent with decades of evidence of its antibacterial, antiviral, and antifungal action. Chlorhexidine offers action against aerobic pathogens like- S. sanguis, S. mutans (Chlorhexidine- binds with the phospholipids in the innercell membrane causing cell wall integrity). The application of chlorhexidine (CHX) gel on ulcers and wound surfaces after oral surgical procedures has received considerable attention— supported scientifically by the antimicrobial properties of chlorhexidine. Chlorhexidine acts against bacteria (Gram-positive and Gram-negative), with bacteriostatic action at low concentrations and bactericidal action at high concentrations Chlorhexidine is also known for its antiviral and antifungal effects.

     

    Mode of action:

    Chlorhexidine acts on the target micro-organisms by increasing their cell membrane permeability which causes the precipitation of cytoplasmic macromolecules and subsequent microbial death via cell lysis. Therefore, the effect of CHX is mainly based on minimizing the microbial load —playing an anti-infection role, which seems critical in the early stages of wound healing.

    Metronidazole:

    Metronidazole offers action against anaerobic pathogens like- P. gingivalis, etc (inhibits protein synthesis by interacting with DNA, and causes a loss of helical DNA structure and strand breakage)

    Lignocaine:

    Heximetro also contains 2% Lignocaine, which can provide instant and profound anesthesia over the surfaces of oral lesions.

    Indications:

    1. Infected painful ulcers in the mouth
    2. Periodontal diseases: gingivitis, periodontitis with pockets
    3. Oral candidiasis, esp painful denture stomatitis lesions
    4. Aphthous ulcers
    5. Ulcers due to dentures
    6. Common oral injuries, including those from orthodontic appliances and oral surgery appliances
    7. Dry socket (alveolar osteitis) prevention and treatment
    8. Infections in the interdental areas: to be applied with interdental brushes like Thermoseal proxa
    9. Maintenance of oral hygiene, especially interdentally — in cancer patients,
    gingivitis & periodontitis patients, between and around restorations

    Heximetro in various clinical conditions:

    A. Heximetro in dry socket:

    The extraction of third molars is a common dental procedure. The American Association of Oral and Maxillofacial Surgeons states that “about 85% of third molars will eventually need to be removed”. Available data also shows that 5 to 30% third molar extractions can create a “dry socket” – a complication associated with severe pain.

    How can we prevent this unwanted complication?

    1. A meta-analysis published in “Oral Diseases” in August 2016, reviewed 11 trials and found that 0.2% chlorhexidine gel was effective in preventing alveolar osteitis after lower third molar extraction(s). https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.12553

    2. Journal of Oral & Maxillofacial Surgery in May 2017, reviewed Twenty-three studies published from 1979 to 2015 and concluded that chlorhexidine, used in any formulation and concentration can prevent dry socket in patients who have undergone third molar extraction. https://www.joms.org/article/S0278-2391(17)30020-4/fulltext

    3. Another systematic review & meta-analysis published in May 2017 found that Chlorhexidine gel is superior to placebo in reducing the incidence of alveolar osteitis after mandibular third molar
    extraction. https://bmcoralhealth.biomedcentral.com/articles/10.1186/s12903-017-0376-3

    4. The largest network meta-analysis done till now reviewed 37 randomized controlled trials that included 6175 mandibular third molar surgeries in 4716 patients. This study published in Sept 2020 showed that 0.2% Chlorhexidine gel placed in the socket can prevent dry socket after mandibular third molar surgery. https://www.sciencedirect.com/science/article/abs/pii/S1010518220301578

    Chlorhexidine in its therapeutic concentration of 1% fortified with an additional metronidazole cover, and lignocaine surface anesthesia, heximetro can ensure the healing of the dry socket.

    B. Heximetro as a post-surgical gel

    High-quality articles demonstrate the evidence that Chlorhexidine gel application exerts a beneficial effect on oral surgical wound healing. Chlorhexidine gel application significantly decreases the risk of surgical complications and/or poor wound healing. With additional metronidazole cover and lignocaine surface anesthesia, heximetro can ensure uneventful healing.

    C. Heximetro in denture stomatitis

    Denture stomatitis (DS) seen in about 15-70% of denture wearers is a condition characterized by a generalized inflammation of the denture-covered palatal mucosa. The clinical signs can vary from petechiae to generalized inflammation with papillary hyperplasia. It is a harmless form of oral candidiasis associated with a quantitative increase of yeasts (a mixture of Candida species eg. C. albicans, C. tropicalis, C. krusei, C. guilliermondii, C. glabrata) on the mucosa and the denture’s fit surface. Complete and removable dentures accumulate, among all, C. albicans on the porous surface of the acrylic resin.
    Denture hygiene is an important factor in the prevention and treatment of DS. Chlorhexidine digluconate, an effective antimicrobial agent active against various bacteria, viruses, and fungi including C. albicans, is recommended in the treatment of denture stomatitis because of its proven clinical and microbiological efficacy. Lignocaine can ensure comfortable denture wear by providing surface anesthesia on the inflamed tissue surfaces.

    D. Hexigel in cancer patients

    Patients with sensitive soft tissues can use an interdental brush dipped in Heximetro gel to clean the areas between teeth, crowns, and bridges to ensure good oral health.

    E. Hexigel in periodontitis patients

    Cleaning the interdental areas is a critical component of oral care in periodontitis patients. Patients with periodontitis can use an interdental brush dipped in Heximetro gel to clean the areas between teeth, crowns, and bridges to ensure good periodontal health.

    F. Hexigel in restorative dentistry

    Restorations with overhangs and rough edges can create plaque-retentive areas around the crowns, bridges, and fillings. Cleaning the interdental areas is critical to maintaining soft tissue health interdentally.

    Dose:

    2 to 3 times a day or as directed by the doctor.

    Presentation:

    15 gms in a lami tube

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  • Hexiprep 500ml

    Microbicidal Skin Prepping Solution

    Composition:
    Chlorhexidine Gluconate Solution 2% v/v, equivalent to Chlorhexidine Gluconate 0.4% w/v, in Isopropyl Alcohol base. (Formulation available – I.P. – Domestic, B.P. – Export)

    Mode of Action:
    15 seconds contact microbicidal 12 hours skin binder

    Indications:
    Presurgical preparation and asepsis solution for skin disinfection and for colour demarcation of the area of incision. 66

    Directions for use:
    Apply undiluted solution with clean surgical cotton swab on the skin prior to surgery.

    Storage:
    Protect from heat and light. Keep away from flame. Keep bottle capped when not in use.

    Caution:
    Keep away from eyes and children. For external use only.

    Presentation:
    Plastic bottle of 500ml (16.9 fl.oz).

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  • ICPAMOX-CV

    Composition:

    Amoxycillin 500mg + Clavulanic acid 125mg Tablet

    Introduction:

    ICPAMOX-CV 625 is an antibiotic with broad-spectrum activity against the commonly occurring bacterial pathogens involved in the infections of the oral cavity and other parts of the body. The beta-lactamase inhibitory action of clavulanic acid extends the spectrum of Amoxycillin to act against a wider range of organisms, including many resistant to other beta-lactam antibiotics.

    Indications:

    ICPAMOX-CV improves treatment success rate in,
    1. Acute periapical abscess; along with endo treatment
    2. Before starting endo treatment; to reduce post-operative pain
    3. Tooth extraction & other oral surgeries; to reduce post-operative infection and bacteremia
    4. Before wisdom tooth surgeries; to prevent post-operative infection & dry socket
    5. Pericoronitis & Peri-implantitis
    6. Periodontitis (as an adjunct to scaling & root planing), periodontal surgeries, periodontal abscess.
    7. Facial cellulitis

    Dose:

    One tablet BID for 3-7 Days.

    Presentation:

    Alu Alu blister pack of 10 tablets

    Common side effects:
    • Diarrhea
    • Stomach upset
    • Nausea and vomiting
    • Mild skin rash
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  • Kids Dyny Toothbrush

    Uses:

    1. Kids Dyny toothbrush has a small head that ensures easy maneuvering in your child’s mouth.
    2. Easy grip handle to ensure that the brush won’t slip.
    3. Regular use helps to remove plaque from your kid’s tooth surfaces that can lead to cavities and gum disease.
    4. The best quality nylon bristles of 0.007-inch diameter – soft and firm enough to effectively brush your kid’s teeth and reach between the gaps.
    5. The bristles tend to fray as babies chew on them. So, dentists and hygienists recommend replacing toothbrushes every 3 months.

    Presentation:

    1 toothbrush.

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  • Moyzen Cream 100gm

    Moisturising Cream

    Softens and Rehydrates dry skin

    Composition:
    Light Liquid Paraffin 6% w/w White Soft Paraffin 15% w/w Cream base q.s. Preservative q.s. (Formulation available – I.P. – Domestic, B. P. – Export)

    Mode of action:
    Stratum corneum is the surface layer of the epidermis. Water content of Stratum corneum (10%) is controlling factor in maintaining skin flexibility. When water content falls below 10%, Stratum corneum becomes less flexible and rough. This phenomenon is termed as ‘dry skin’. Certain skin disorders and systemic diseases also produce dry skin.
    Moyzen produces thin occlusive film on the Stratum corneum, which prevents loss of moisture from skin surface.

    Indications:
    Dry skin conditions.

    Directions for use:
    Apply to the affected area and rub well. Use as often as required. Recommended units for application – Face and neck 2.5 fingertip units, Arm (shoulder-wrist) – 3 fingertip units, Hand -1 fingertip unit, Leg- 6 fingertip units, Foot – 2 fingertip units.

    Precautions:
    Do not rub skin with towel after Moyzen application.

    Presentation:
    Lamitube of 100g (3.53 oz)

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  • Moyzen Liquid 100ml

    Softens and Rehydrates Dry Skin

    Composition:
    Light Liquid Paraffin 63.4% w/w Base q.s. (Formulation available – I.P. Domestic, B.P. – Export)

    Mode of action:
    Stratum corneum is the surface layer of the epidermis. Water content of Stratum corneum (10%) is controlling factor in maintaining skin flexibility. When water content falls below 10%, Stratum corneum becomes less flexible and rough. This phenomenon is termed as ‘dry skin’. Certain skin disorders and systemic diseases also produce dry skin.
    Moyzen produces thin occlusive film on the Stratum corneum, which prevents loss of moisture from skin surface.

    Indications:
    For the relief of dry skin associated with Contact dermatitis, Atopic dermatitis, Senile Pruritus, Ichthyosis and related dry skin conditions.

    Directions for use:
    Apply Moyzen on wet skin, preferably after bathing and thereafter pat skin dry.

    Precautions:
    Do not rub skin with towel after Moyzen application.

    Presentation:
    HDPE bottle of 100ml (3.38 fl.oz.)

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  • Moyzen Plus

    Treatment Bar. Softens and Rehydrates Dry Skin.

    Composition:

    Olive Oil:
    • Penetrates deep into the skin providing long lasting moisture.
    Glycerin:
    • A natural moisturizer draws water and prevents dryness of skin.
    Fortified with Aloe Vera and Vitamin E:
    • Maintains skin elasticity and suppleness.Keeps skin pores free from dirt and keeps skin soft and tender.

    Indications:
    Dry skin conditions.

    Directions for use:
    Ensure a rich lather using a little hot water and clean the affected area. Do not rinse excessively. Pat skin dry. Can be used in hard water also.

    Caution:
    Avoid contact with eyes. Flush eyes with water in case of accidental entry of lather. If there is irritation of the skin, discontinue use and consult your doctor. Keep out of reach of children.

    Presentation:
    Bathing Bar of 100g (3.53 oz).

     

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  • Mucofibro Antioxidants

    Composition:

    Mucofibro is a formulation of antioxidants available in the form of softgel capsules.
    Each soft gelatin capsule contains
    Lycopene – 5 mg,
    Beta-carotene – 10 mg,
    Alpha lipoic acid 50 mg,
    Elemental copper – 1 mg,
    Elemental selenium – 75 mcg,
    Vitamin E – 10 IU and
    Zinc sulphate – 27.45 mg.

    Reactive Oxygen Species (ROS) —Free radicals

    ROS are chemical molecules, specifically oxygen species formed by the partial reduction of oxygen that are generated during mitochondrial oxidative metabolism as well as in cellular response to cytokines and bacterial invasion.

    The double-edged sword

    ROS serve as crucial players in our body’s defense against invading pathogens. ROS play pivotal roles in cell signaling, gene regulation, and antimicrobial defense. These molecules have antimicrobial properties that help combat infections in the oral cavity. However, ROS can be a “double-edged sword” since an excessive presence of these molecules can become cytotoxic to our cells.

    The concept of Oxidative Stress:

    To counteract the deleterious effects of excessive free radicals, our bodies possess an antioxidant defense system that can inhibit and reduce the damage caused by the harmful ROS. However, when ROS levels exceed cellular antioxidant capacity, a condition termed oxidative stress occurs. Oxidative stress is implicated in the pathogenesis of several conditions including aging, diabetes mellitus, hypertension, and cancer.

    Antioxidants:

    These are oxidative stress busters used as auxiliary treatments in a variety of conditions such as cardiovascular diseases, pulmonary diseases, aging, and atherosclerosis.

    Mucofibro: Antioxidant supplemements

    With an optimal combination of anti-oxidants, carotenoids, and minerals, Mucofibro detoxifies the cells by scavenging the cell-damaging free radicals. This cell detoxification removes oxidative stress in the cells and enhances the overall tissue healing capacity, which results in faster healing of various oral lesions and conditions. It also improves the clinical outcomes of various non-surgical and surgical treatments.

    Indications

    1. Precancerous lesions: Leukoplakia, Erythroplakia (to prevent/ slow down the malignant transformation)
    2. Precancerous conditions: Oral Submucous Fibrosis (to prevent/ slow down the malignant transformation)
    3. As an adjunct to non-surgical & surgical periodontal treatments for various gum diseases: Gingivitis and Periodontitis
    4. As an adjunct to implant treatments to improve osseointegration.
    5. As an adjunct to bone regeneration & tissue engineering procedures.
    6. In various oral surgical procedures for improved healing.
    7. For improved healing of oral ulcers

    A. The role of antioxidants in periodontal health

    The link between oxidative stress and periodontal disease

    Periodontal disease is a persistent inflammatory condition that impacts the  periodontal tissues. Emerging research has elucidated the connection between oxidative stress and periodontal disease. An article in a high-impact factor journal terms periodontitis as an inflammatory disease of oxidative stress.
    In the early stages of periodontal disease, especially in the case of periodontitis, a prominent oxidative process unfolds, characterized by elevated levels of reactive oxygen and nitrogen species (ROS and RNS). Evidence says that much of the damage done to periodontal tissues and supporting bone structure is due to ROS emission.

    Promising results

    Recent evidence supports the idea that antioxidants can play a pivotal role in the treatment of periodontitis. A meta-analysis comprising fifteen clinical trials demonstrated uniformly positive outcomes associated with antioxidant supplementation during periodontitis treatment. Lycopene is emerging as a promising treatment modality as an adjunct to full-mouth periodontal treatment.
    These findings offer hope and promise for those seeking alternative therapies to complement traditional periodontal treatments.

    B. The role of antioxidants in implantology

    1. Antioxidants like lycopene exert proliferative effects on human osteoblasts.
    2. Antioxidants like lycopene may increase new bone formation in periodontal and dental implant treatments.
    3. Lycopene improves implant osseointegration and prevents delayed osseointegration.
    4. Antioxidants also help in bone formation and prevent bone loss under osteopenic conditions.

    C. Antioxidants in pre-cancerous conditions like Oral Submucous Fibrosis (OSMF)

    Mucofibro improves mouth opening and prevents the malignant transformation of OSMF (and other precancerous lesions/ conditions).
    1. Lycopene, a carotenoid derived from plants, demonstrates anti-carcinogenic properties and prevents the malignant transformation of precancerous lesions and conditions. Lycopene exhibits the highest physical quenching rate constant with singlet oxygen. Lycopene is the first line of treatment for OSMF, apart from demonstrating profound benefits with precancerous lesions such as leukoplakia.
    2. β-carotene, a precursor of vitamin A, is an antioxidant that traps free radicals. It retards the development of cancer cells by minimizing the free radical-induced damage.
    3. α-Lipoic Acid (LA) is known as a universal antioxidant as it can remove free radicals in water as well as lipid medium.
    4. α-Tocopherol (Vitamin E) has the antioxidant action.
    5. Selenium (Se) is an anticarcinogenic agent that prevents unwanted cell growth.
    6. Zinc (Zn), essential for multiple cellular functions, acts as an antioxidant andstabilizes membranes.
    7. Copper (Cu) enhances the activity of antioxidants.

    Dose

    2 times a day for 30 days or as directed by the doctor

    Presentation

    2 x 10 softgels

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  • Mucopain 15gm

    Composition:

    Benzocaine I.P. 20% w/w in a water-miscible base Topical anaesthetics come in various dosage forms, such as gels, sprays, creams, ointments, patches to provide the clinicians with precise options for application under various situations.

    Understanding Benzocaine:

    Benzocaine is an ester type molecule used for topical (surface) anaesthesia in a variety of settings, including dental procedures, preparation for infiltration anesthesia, and pain relief minor traumas to oral mucosa.

    Topical anaesthetic agents such as Benzocaine penetrate the oral mucosa effectively and offer local anaesthetic activity that lasts for 10-20 minutes. The poor water solubility of Mucopain makes it safe for topical use. Local anaesthetics reversibly block nerve transmission, when applied to a limited area of the body. They bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane’s depolarization.

    Mechanism of action:

    1. Benzocaine acts by reversibly binding to and inhibiting sodium channels in the neuronal cell membrane.
    2. Benzocaine first enters the cell in a nonionized form and then becomes ionized after traveling through the membrane bilayer.
    3. Once ionized, benzocaine starts inhibiting the voltage-gated sodium channels by binding to their alpha subunit.
    4. This binding stops cellular depolarization and minimizes the chances of action potential generation.
    5. Benzocaine can bind more easily to sodium channels when they are in an open configuration.
    6. The pKa value of local anesthetics is critical as it helps to determine their onset of action. Since benzocaine’s pKa value is relatively low (2.6) in comparison to other local anesthetics, its onset of action is quick, its rate of action is fast and relatively pH-independent.

    Indications:

    For topical anaesthesia of all accessible mucous membrane, except eyes. For temporary local relief of pain associated with dental conditions and oropharyngeal disorders.
    1. Nutritional deficiency induced ulcers
    2. Traumatic ulcers, such as lip bite, cheek bite
    3. Treatment induced ulcers: due to orthodontic appliances, oral surgical appliances, dentures
    4. Mucosal injuries during instrumentation in dental procedures
    5. Ulcers from autoimmune disorders, such as lichen planus, pemphigoid, pemphigus.
    6. Oral submucous fibrosis (OSMF)
    7. Oral ulcers in cancer patients

    Directions for use:

    For oral mucosal use only, as directed by a dentist. For the temporary relief of pain due to ulcers, or injuries from minor dental procedures.

    Warning:

    Discontinue medication and consult a doctor if sensitivity or irritation occurs. Safe use of Mucopain is not established during pregnancy on the foetus. Do not cover the affected area with cotton or other material. Not for infant use.

    Methemoglobinemia warning

    Use of this product may cause methemoglobinemia, a serious condition that warrants prompt clinical management because it reduces the amount of oxygen carried in the blood. This can occur even if one has used this product before. Stop use and seek immediate medical attention if you or a user in your care develops any of the following:

    • pale, gray, or blue-colored skin (cyanosis)
    • headache
    • rapid heart rate
    • shortness of breath
    • dizziness or lightheadedness
    • fatigue or lack of energy
    Presentation:

    Lamitube of 15g (0.52 oz)

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