Composition:

Benzocaine I.P. 20% w/w in a water-miscible base Topical anaesthetics come in various dosage forms, such as gels, sprays, creams, ointments, patches to provide the clinicians with precise options for application under various situations.

Understanding Benzocaine:

Benzocaine is an ester type molecule used for topical (surface) anaesthesia in a variety of settings, including dental procedures, preparation for infiltration anesthesia, and pain relief minor traumas to oral mucosa.

Topical anaesthetic agents such as Benzocaine penetrate the oral mucosa effectively and offer local anaesthetic activity that lasts for 10-20 minutes. The poor water solubility of Mucopain makes it safe for topical use. Local anaesthetics reversibly block nerve transmission, when applied to a limited area of the body. They bind to the sodium channels in the nerve membrane and prevent the entry of sodium ions in response to the membrane’s depolarization.

Mechanism of action:

1. Benzocaine acts by reversibly binding to and inhibiting sodium channels in the neuronal cell membrane.
2. Benzocaine first enters the cell in a nonionized form and then becomes ionized after traveling through the membrane bilayer.
3. Once ionized, benzocaine starts inhibiting the voltage-gated sodium channels by binding to their alpha subunit.
4. This binding stops cellular depolarization and minimizes the chances of action potential generation.
5. Benzocaine can bind more easily to sodium channels when they are in an open configuration.
6. The pKa value of local anesthetics is critical as it helps to determine their onset of action. Since benzocaine’s pKa value is relatively low (2.6) in comparison to other local anesthetics, its onset of action is quick, its rate of action is fast and relatively pH-independent.

Indications:

For topical anaesthesia of all accessible mucous membrane, except eyes. For temporary local relief of pain associated with dental conditions and oropharyngeal disorders.
1. Nutritional deficiency induced ulcers
2. Traumatic ulcers, such as lip bite, cheek bite
3. Treatment induced ulcers: due to orthodontic appliances, oral surgical appliances, dentures
4. Mucosal injuries during instrumentation in dental procedures
5. Ulcers from autoimmune disorders, such as lichen planus, pemphigoid, pemphigus.
6. Oral submucous fibrosis (OSMF)
7. Oral ulcers in cancer patients

Directions for use:

For oral mucosal use only, as directed by a dentist. For the temporary relief of pain due to ulcers, or injuries from minor dental procedures.

Warning:

Discontinue medication and consult a doctor if sensitivity or irritation occurs. Safe use of Mucopain is not established during pregnancy on the foetus. Do not cover the affected area with cotton or other material. Not for infant use.

Methemoglobinemia warning

Use of this product may cause methemoglobinemia, a serious condition that warrants prompt clinical management because it reduces the amount of oxygen carried in the blood. This can occur even if one has used this product before. Stop use and seek immediate medical attention if you or a user in your care develops any of the following:

• pale, gray, or blue-colored skin (cyanosis)
• headache
• rapid heart rate
• shortness of breath
• dizziness or lightheadedness
• fatigue or lack of energy

Presentation:

Lamitube of 15g (0.52 oz)